Copper Sulfate

1. General Information
Substance: Copper Sulfate, Pentahydrate
CAS No.: 7758-99-8
Trade Names/ Synonyms: Copper(II)Sulfate, Pentahydrate;
Triangle: Bluestone: Copper(II)Sulfate, Pentahydrate(1:1:5);
Blue Copper as: Copper Sulphate; Copper(2+)Sulfate, Pentahydrate; Copperfine-Zinc; Blue Vitriol; Roman Vitriol; NA 9109; OHS05690
Chemical Family: Inorganic Salt
Molecular Formula: CU-04-S.5H2O
Molecular Weight: 249.68
CERCLA Ratings
(Scale 0-3):
NFPA Ratings
(Scale 0-4):
2. Hazardous Ingredients
Cupric Sulfate, Pentahydrate: 100%
Other Contaminants: None
Exposure Limits: 1 mg(cu)/mВі OSHA TWA (dust and mist)
1 mg(cu)/mВі ACGIH TWA (dust and mist)
2 mg(cu)/mВі ACGIH STEL (dust and mist)
3.Physical Data
Description: Blue Crystals, Granules, or Powder
Boiling Point: 150В°C-H2O
Melting Point: 110В°C-H2O
Specific Gravity&nsp;(H2O=1): 2.3
Solubility in Water: 32%
Solvent Solubility: Methanol, Slightly soluble in Ethanol, Glycerol
Fire and Explosion Hazard: Negligible fire and explosion hazard when exposed to heat or flame
Firefighting Media: Dry chemical, carbon dioxide, water spray or foam (1984 Emergency Response Guidebook, DOT P 5800.3). For larger fires, use water spray, fog or alcohol foam (1984 Emergency Response Guidebook, DOT P 5800.3)
Firefighting: Move containers from fire area if possible. Do not scatter spilled area with more water than needed for fire control. Dike fire control water for later disposal (1984 Emergency Response Guidebook, DOT P 5800.3. Guide page 31). Use agents suitable for type of fire. Avoid breathing vapors or dust (Bureau of Explosives, Emergency Handling of Hazardous Materials in Surface Transportation, 1981).
4. Transportation Data
Department of Transportation Hazard Classification 49CFR172.101: ORM-E
Department of Transportation Labeling Requirements 49CFR172.101 and 172.402: None
5. Toxicity
Copper dust is eye, skin, and mucous membrane irritant. Copper Sulfate is toxic. Poisoning nay affect the liver and/or kidneys and gastrointestinal tract. Persons with a history of chronic respiratory or skin disease may be at increased risk from exposure.
6. Health Effects and First Aid
Inhalation: Irritant. Acute exposure-inhalation of dusts and mist of copper salts may cause irritation of the upper respiratory tract. Workers exposed to copper salts in dust form complained of metallic taste with irritation of nasal and oral mucosa. There is one report of three workers exposed to extremely fine copper dust at concentrations of 0.075 to 0.120 mg/mВі developing metal fume fever. Symptoms of metal fume are chills, fever, aching muscles, dryness in the mouth and throat, and headache. The illness which is generally caused by copper fumes was attributed to the fineness of the copper particles.
Chronic Exposure: Prolonged exposure of copper salts may produce severe congestion of the nasal mucosa with Rhinitis and possible sloughing and ulceration.
First Aid: Remove from exposure area to fresh air immediately. If breathing has stopped, give artificial respiration. Keep affected person warm and at rest. Fet medical attention immediately.
Skin Contact Irritant. Acute exposure-direct contact of copper salts with the skin may give rise to itching, papulovesicular and excematoid lesion.
Chronic Exposure: Prolonged exposure to copper salts may cause some degree of necrosis. Allergic contact dermatitis due to copper exposure, although rare, has been reported. It may absorbed through the skin. Systematic poisoning followed repeated applications of copper sulfate solution to extensive areas of burned skin. Symptoms of systematic poisoning may include blue discoloring of the gums and tongue, hemolytic anemia, hemorrhagic gastritis, colic and diarrhea with bloody stools. In severe cases of poisioning, liver and kidney damage with severe anemia may occur with possible somnolence and coma. Death may occur from circulatory failure. Greenish discoloration of the skin and hair of some copper workers has been observed.
First Aid: Remove contaminated clothing and shoes immediately. Wash affected area with soap or mild detergent and large amounts of water until no evidence of chemical remains (approximately 15-20 mins.). Get medical attention immediately.
Eye Contact: Irritant. Acute exposure-copper salts splashed in the eyes may cause conjunctivitis, corneal ulceration and turbidity, and palpebral edema. Copper particles embedded in the eye may result in pronounced foreign body reaction with characteristic discoloration of ocular tissue.
Chronic Exposure: Prolonged use of solid copper sulfate for treatment of trachoma produced inflammation and purulent reaction, and discoloration of the cornea. The discoloration in advanced cases covered the whole cornea but caused slight ot no interference with the vision. When a particle of copper sulfate was left accidentally in the conjunctival sac, it caused more sever local inflammation and necrosis, corneal opacity, and symblepharon. A very low concentration of copper sulfate (0.0001 M) caused the precorneal tear film to curdle. There was no injury to the cornea and little discomfort felt by human subjects exposed to this material.
First Aid: Wash eyes immediately with large amount of water, occasionally lifting upper and lower lids, until no evidence of chemical remains (approximately 15-20 mins.). Get medical attention immediately.
Ingestion: Toxic. Acute exposure-ingestion of a toxic dose of copper sulfate may cause salivation, nausea, vomiting, gastric pain, and local corrosion of hemorrhages. Other symptoms of systematic intoxification include blue discoloration of the gums and tongue. Hemolytic anemia, colic and diarrhea with bloody stools. In severe cases of poisoning, liver and kidney damage with severe anemia may occur with possible somnolence and coma. Death may occur from circulatory failure. Two men who ingested 60 and 80g in solution died in 6 and 9 days, respectively. The minimal lethal oral dose for an adult appears to be 10g.
Chronic Exposure: Chronic human poisoning has only been reported in individuals with Wilson's Disease. This disease is a rare genetic condition in which there may be abnormally high absorbition, retention, and storage of copper by the body. The disease is progressive and may be fatal if untreated.
First Aid: Dilute the poision with large amount of water or milk and remove by gastric lavage unless the victim is already vomiting (Dreisbach, Handbook of Poisoning, 11th Ed.). Get medical attention immediately. Administration of gastric lavage should be preformed by qualified medical personnel.
Antidote: For copper poisoning, give calcium disodium edetate orally and intravenously. Penicillamine is also effective in copper poisoning (Dreisbach, Handbook of Poisoning, 11th Ed.).
7. Reactivity
Reactivity: Stable under normal temperatures and pressures.
Incompatibilities: Hydroxylamine: Causes vigorous reduction.
Magnesium: Evolves flammable hydrogen gas from cupric sulfate solutions.
Sodium Hydrobromite Solutions: Decomposed by cupric ions.
Decomposition: Thermal decomposition products include highly toxic oxides of sulfur.
Polymerization: None known to occur.
8. Spill and Leak Procedures
Solid Spill: Dig holding area such as lagoon, pond or pit for containment. Use protective cover such as a plastic sheet to prevent material from dissolving fire extinguisher water or rain.
Water Spill: Add suitable agent to neutralize spilled material to pH-7. Use dredges or lifts to extract immobilized masses of pollution and precipitates.
Occupational Spill: Stop leak if you can do it without risk. For small spills, take up with sand or other absorbent material and place into clean, dry containers for later disposal. Keep unnecessary people away. Isolate hazard area and deny entry.
9. Protective Equipment
Ventilation: Provide local exhaust or process enclosure ventilation to meet published exposure limits.
Respirator: The following respirators and maximum use concentrations are recommended by NIOSH/OSHA or 29CFR1910; subpart Z. The specific respirator selected must be based on contamination levels found in the work place and be jointly approved by the National Institute of Occupational Safety and Health and the Mine Safety and Health Administration. 50mg(cu)/mВі-High Efficiency particulate respirator with a full facepiece. Supplied-air respirator with full facepiece. Helmet or hood. Self-contained breathing apparatus with full facepiece. 20000mg(cu)/mВі-Type 'C' supplied-air respirator with a full facepiece operated in pressure-demand or other positive pressure mode or with a full facepiece, helmet or hood operated in continuous flow mode.
Immediately Dangerous Life or Health Conditions: Self contained breathing apparatus with full facepiece operated in pressure-demand or other positive pressure mode.
Clothing: Employee must wear appropriate protective (impervious) clothing and equipment to prevent repeated or prolonged skin contact with this substance.
Gloves: Employee must wear appropriate gloves to prevent contact with substance.
Eye Protection: Employee must wear splash-proof or dust resistant safety goggles to prevent eye contact with this substance.

January, 2001

MSDS Index
Copper Sulfate Index

The information contained in this document we believe to be accurate, but no warranty is given nor is anything to be construed as a recommendation to infringe upon any existing patent. Since conditions of use are beyond our control, all risks of use are assumed by the user.